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    Weight loss jab side effects affecting ‘one in 10’ users – and when to speak to doctor

    Editorial TeamBy Editorial TeamMarch 12, 2026No Comments3 Mins Read
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    Weight loss jab side effects affecting ‘one in 10’ users – and when to speak to doctor

    Weight loss injections like Wegovy can result in “very common” side effects

    Fiona Callingham Lifestyle writer

    04:30, 12 Mar 2026

    People using weight loss injections could experience a range of side effects that affect roughly “one in 10”. Medical professionals have highlighted these concerns as being “very common” among those receiving treatment.

    Weight loss medications, also known as GLP-1 inhibitors, function by replicating GLP-1 (glucagon-like peptide-1), a hormone naturally produced in the gut that is crucial for regulating blood sugar levels and reducing appetite.

    GLP-1 inhibitors have witnessed a surge in popularity recently, primarily because of their demonstrated effectiveness in controlling blood sugar in people with diabetes and supporting weight reduction. Administered via injection, certain formulations of these medications can be prescribed through the NHS to qualifying individuals.

    However, like any prescribed medication, it’s crucial to understand the possible side effects linked to these injections. The British Heart Foundation (BHF) website points out that “not everyone” will inevitably experience side effects from the treatment.

    Less serious side effects

    Even so, it is “very common” for people to experience digestive issues, such as nausea, diarrhoea, constipation, and abdominal discomfort. The BHF explained: “These side effects affect one in 10 people, according to the patient leaflets that come with Mounjaro and Wegovy. The injections can also cause tiredness or dizziness, hair loss, low blood sugar and a fast heart rate in some people.

    “Speak to your doctor if you’re experiencing any side effects, as you may need to take a lower dose or stop taking them.”

    Acute pancreatitis

    Acute pancreatitis is a rare but potential risk, with the possibility of developing an inflamed pancreas. Patient data suggests that as many as one in 100 individuals using these injections could encounter this condition.

    “Speak to a GP or call 111 if you notice any symptoms, such as a sudden severe pain in the middle of your abdomen,” advised the BHF.

    Vision

    Vision loss is another concern. The Medicines and Healthcare products Regulatory Agency (MHRA) has warned that “very rarely” individuals using semaglutide (the generic name for Wegovy) may experience a “sudden deterioration” in their eyesight, leading to total or partial vision loss, typically affecting one eye at a time.

    The BHF stated: “If you experience this issue you need to seek urgent medical care and be referred to a specialist eye doctor.”

    Poor nutrition

    Poor nutrition is another potential downside due to the way these medications work, likely causing you to eat less. The BHF cautioned that this could result in nutritional deficiencies.

    The charity added: “And rapid weight loss may lead to reduced muscle and bone mass too. That’s why eating a healthy balanced diet is still important.

    “Small, regular meals containing enough lean protein, calcium and vitamin D, and regular exercise can help to protect your muscle and bone health.”

    Contraceptive pill

    The BHF also highlighted that the MHRA warned Mounjaro might reduce the efficacy of the contraceptive pill. It continued: “It recommends using another non-oral form of contraception, like a condom, instead.

    “And the MHRA also says you should not use weight-loss injections if you are pregnant, trying to conceive or breastfeeding.”

    If you experience any negative side effects from your medication, it’s recommended to contact your GP straight away.

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